Leucine--tRNA ligase

UniProt P07813 Organism Escherichia coli (strain K12) Gene JW0637, b0642, leuS EC 6.1.1.4

Also known as: JW0637, b0642, leuS

Classification

Family (Pfam): PF08264 Anticodon_1, PF00133 tRNA-synt_1, PF13603 tRNA-synt_1_2, PF09334 tRNA-synt_1g
InterPro: aa-tRNA-synth_I_CS, aa-tRNA-synth_Ia, Leu-tRNA-ligase, Leu_tRNA-synth_edit, M/V/L/I-tRNA-synth_anticd-bd, Methionyl/Leucyl_tRNA_Synth, Rossmann-like_a/b/a_fold, tRNAsynth_Ia_anticodon-bd, Val/Leu/Ile-tRNA-synth_edit
Functional cluster: Aminoacyl-tRNA Synthetases

Experimental structures · PDB · 17

2AJG X-ray 2.00A
2AJH X-ray 2.40A
2AJI X-ray 3.20A
3ZGZ X-ray 2.40A
3ZJT X-ray 2.20A
3ZJU X-ray 2.40A
3ZJV X-ray 2.31A
4AQ7 X-ray 2.50A
4ARC X-ray 2.00A
4ARI X-ray 2.08A
4AS1 X-ray 2.02A
4CQN X-ray 2.50A
… and 5 more

A predicted model is available from AlphaFold.

Gene Ontology · 5

Drugs targeting this protein · 1

EPETRABOROLE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Uncharacterized protein YbeL 1 shared papers

Literature · 5 cited papers

Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Escherichia coli proteome analysis using the gene-protein database. Electrophoresis · 1997
The complete genome sequence of Escherichia coli K-12. Science · 1997
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. · 1996
Molecular cloning and nucleotide sequence of the gene for Escherichia coli leucyl-tRNA synthetase. Nucleic Acids Res. · 1987

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