Thyroid peroxidase

Function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Classification

Family (Pfam)

PF03098 An_peroxidase, PF07645 EGF_CA, PF00084 Sushi

InterPro

EGF, EGF-like_Ca-bd_dom, EGF-type_Asp/Asn_hydroxyl_site, EGF_Ca-bd_CS, Haem_peroxidase_animal, Haem_peroxidase_sf, Haem_peroxidase_sf_animal, NOTCH1_EGF-like, Sushi/SCR/CCP_sf, Sushi_SCR_CCP_dom, TPO

Functional cluster

Secreted Growth Factors & Cytokines

Gene Ontology · 12

• GO:0009986 cell surface
• GO:0005615 extracellular space
• GO:0005886 plasma membrane
• GO:0005509 calcium ion binding
• GO:0020037 heme binding
• GO:0004447 iodide peroxidase activity
• GO:0004601 peroxidase activity
• GO:0035162 embryonic hemopoiesis
• GO:0042446 hormone biosynthetic process
• GO:0042744 hydrogen peroxide catabolic process
• GO:0006979 response to oxidative stress
• GO:0006590 thyroid hormone generation

Disease associations

• thyroid dyshormonogenesis 2A MONDO:0010133

Drugs targeting this protein · 3

• METHIMAZOLE inhibitor
• PROPYLTHIOURACIL inhibitor
• CARBIMAZOLE inhibitor

Related proteins · sequence + function similarity

• Thyroid peroxidase 0.97
• Thyroid peroxidase 0.96
• Thyroid peroxidase 0.96
• Thyroid peroxidase 0.95
• Lactoperoxidase 0.90
• Lactoperoxidase 0.90
• Lactoperoxidase 0.89
• Lactoperoxidase 0.88
• Lactoperoxidase 0.88
• Lactoperoxidase 0.88
• Myeloperoxidase 0.85
• Eosinophil peroxidase 0.84

Co-cited proteins · studied together in the literature

• Thyroglobulin 1 shared papers
• Pendrin 1 shared papers
• Myeloperoxidase 1 shared papers
• Thioredoxin domain-containing protein 11 1 shared papers
• Dual oxidase 1 1 shared papers
• Dual oxidase 1 1 shared papers
• Dual oxidase 2 1 shared papers
• Cytochrome b-245 light chain 1 shared papers

Literature · 25 cited papers

• Mutations in the genes for thyroglobulin and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability. J. Hum. Genet. · 2016
• Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4/PDS genes. J. Clin. Endocrinol. Metab. · 2006
• Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism. Endocr. J. · 2005
• Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. J. Biol. Chem. · 2005
• Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect. Hum. Mutat. · 2003
• Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings. Clin. Endocrinol. (Oxf.) · 2003
• Monoallelic expression of mutant thyroid peroxidase allele causing total iodide organification defect. J. Clin. Endocrinol. Metab. · 2003
• Genetics of specific phenotypes of congenital hypothyroidism: a population-based approach. Thyroid · 2002
• Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterization by molecular cloning of new transcripts with single- and multispliced mRNAs. J. Biol. Chem. · 2003
• High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect. J. Clin. Endocrinol. Metab. · 2002
• Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism. Eur. J. Endocrinol. · 2002
• Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations. J. Endocrinol. · 2002
• … and 13 more in the literature graph