Gastric triacylglycerol lipase

Function

Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol. Shows a preferential hydrolysis at the sn-3 position of triacylglycerol.

Classification

Family (Pfam)

PF00561 Abhydrolase_1

InterPro

AB_hydrolase_1, AB_hydrolase_fold, Lipase_euk

Functional cluster

Secreted Hydrolases & Toxins

Experimental structures · PDB · 1

• 1HLG X-ray 3.00A

A predicted model is available from AlphaFold.

Gene Ontology · 8

• GO:0005576 extracellular region
• GO:0005739 mitochondrion
• GO:0008289 lipid binding
• GO:0016615 malate dehydrogenase activity
• GO:0004806 triacylglycerol lipase activity
• GO:0016042 lipid catabolic process
• GO:0006629 lipid metabolic process
• GO:0006641 triglyceride metabolic process

Drugs targeting this protein · 2

• ORLISTAT inhibitor
• CETILISTAT inhibitor

Related proteins · sequence + function similarity

• Gastric triacylglycerol lipase 0.98
• Gastric triacylglycerol lipase 0.98
• Gastric triacylglycerol lipase 0.98
• Gastric triacylglycerol lipase 0.97
• Lysosomal acid lipase/cholesteryl ester hydrolase 0.95
• Lysosomal acid lipase/cholesteryl ester hydrolase 0.94
• Lysosomal acid lipase/cholesteryl ester hydrolase 0.94
• Lipase member N 0.94
• Lipase member K 0.94
• Lipase member K 0.94
• Putative lysosomal acid lipase/cholesteryl ester hydrolase 0.93
• Lysosomal acid lipase/cholesteryl ester hydrolase 0.93

Literature · 8 cited papers

• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 10. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest. J. Biol. Chem. · 1999
• Molecular cloning of a human gastric lipase and expression of the enzyme in yeast. Biochim. Biophys. Acta · 1987
• Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity. Eur. J. Biochem. · 1989
• Stereoselectivity of lipases. II. Stereoselective hydrolysis of triglycerides by gastric and pancreatic lipases. J. Biol. Chem. · 1990