Tubulin beta chain

UniProt P05304 Organism Giardia intestinalis

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Classification

Family (Pfam): PF00091 Tubulin, PF03953 Tubulin_C
InterPro: Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
Functional cluster: Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 6

Drugs targeting this protein · 1

FENBENDAZOLE binding agent

Related proteins · sequence + function similarity

Literature · 1 cited papers

Cloning and sequence of beta tubulin cDNA from Giardia lamblia. Nucleic Acids Res. · 1988

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.