Fibroblast growth factor 1

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.

Classification

Family (Pfam)

PF00167 FGF

InterPro

Fibroblast_GF_fam, IL1/FGF

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 96

• 1AXM X-ray 3.00A
• 1DJS X-ray 2.40A
• 1DZC NMR
• 1DZD NMR
• 1E0O X-ray 2.80A
• 1EVT X-ray 2.80A
• 1HKN X-ray 2.00A
• 1JQZ X-ray 1.65A
• 1JT3 X-ray 1.95A
• 1JT4 X-ray 1.78A
• 1JT5 X-ray 1.85A
• 1JT7 X-ray 1.70A
• … and 84 more

A predicted model is available from AlphaFold.

Gene Ontology · 38

• GO:0005938 cell cortex
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0031012 extracellular matrix
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005104 fibroblast growth factor receptor binding
• GO:0008083 growth factor activity
• GO:0008201 heparin binding
• GO:0005178 integrin binding
• GO:0044548 S100 protein binding
• GO:0032148 activation of protein kinase B activity
• GO:0009653 anatomical structure morphogenesis
• GO:0001525 angiogenesis
• GO:0060681 branch elongation involved in ureteric bud branching
• GO:0034605 cellular response to heat
• GO:0008543 fibroblast growth factor receptor signaling pathway
• GO:0072163 mesonephric epithelium development
• GO:0022008 neurogenesis
• GO:0045766 positive regulation of angiogenesis
• GO:0051781 positive regulation of cell division
• GO:0030335 positive regulation of cell migration
• GO:0008284 positive regulation of cell population proliferation
• GO:0045542 positive regulation of cholesterol biosynthetic process
• GO:0010595 positive regulation of endothelial cell migration
• GO:0070374 positive regulation of ERK1 and ERK2 cascade
• GO:1902533 positive regulation of intracellular signal transduction
• GO:0043406 positive regulation of MAP kinase activity
• GO:0043410 positive regulation of MAPK cascade
• GO:1903672 positive regulation of sprouting angiogenesis
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0030334 regulation of cell migration
• GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor
• GO:1901509 regulation of endothelial tube morphogenesis
• GO:0007165 signal transduction
• GO:0042060 wound healing

Drugs targeting this protein · 1

• SURAMIN HEXASODIUM inhibitor

Related proteins · sequence + function similarity

• Fibroblast growth factor 1 0.99
• Fibroblast growth factor 1 0.99
• Fibroblast growth factor 1 0.99
• Fibroblast growth factor 1 0.99
• Fibroblast growth factor 1 0.99
• Fibroblast growth factor 1 0.98
• Fibroblast growth factor 1 0.98
• Fibroblast growth factor 1 0.97
• Fibroblast growth factor 1 0.96
• Fibroblast growth factor 1 0.95
• Putative fibroblast growth factor 1 0.92
• Fibroblast growth factor 1 0.91

Co-cited proteins · studied together in the literature

• Fibroblast growth factor 2 10 shared papers
• Fibroblast growth factor receptor 2 7 shared papers
• Protein S100-A13 1 shared papers
• Fibroblast growth factor receptor 1 8 shared papers
• Protein S100-A13 1 shared papers
• Fibroblast growth factor receptor 3 5 shared papers
• Leucine-rich repeat-containing protein 59 2 shared papers
• Fibroblast growth factor 1 1 shared papers
• Centrosomal protein of 57 kDa 1 shared papers
• Fibroblast growth factor-binding protein 1 1 shared papers
• Acidic fibroblast growth factor intracellular-binding protein 1 shared papers
• Fibroblast growth factor receptor 4 4 shared papers

Literature · 42 cited papers

• A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. PLoS ONE · 2013
• Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. Traffic · 2012
• Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells. J. Formos. Med. Assoc. · 2010
• A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist. PLoS ONE · 2010
• The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion. J. Biol. Chem. · 2010
• Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J. Biol. Chem. · 2010
• Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer · 2010
• Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J. Biol. Chem. · 2008
• The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Lett. · 2008
• Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J. Biol. Chem. · 2006
• Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 30 more in the literature graph