Pancreatic alpha-amylase

UniProt P04746 Organism Homo sapiens Gene AMY2A EC 3.2.1.1

Also known as: AMY2A

Classification

Family (Pfam): PF00128 Alpha-amylase, PF02806 Alpha-amylase_C
InterPro: A-amylase/branching_C, A-amylase_C, Alpha_amylase, GH, GH13_cat_dom, Glyco_hydro_b
Functional cluster: Central Metabolic Enzymes (KARI/Glycolysis)

Experimental structures · PDB · 51

1B2Y X-ray 3.20A
1BSI X-ray 2.00A
1CPU X-ray 2.00A
1HNY X-ray 1.80A
1KB3 X-ray 2.10A
1KBB X-ray 1.90A
1KBK X-ray 1.90A
1KGU X-ray 2.00A
1KGW X-ray 2.10A
1KGX X-ray 2.00A
1U2Y X-ray 1.95A
1U30 X-ray 1.90A
… and 39 more

A predicted model is available from AlphaFold.

Gene Ontology · 9

Drugs targeting this protein · 1

ACARBOSE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Alpha-amylase 2B 2 shared papers
Alpha-amylase 1A 2 shared papers
Pancreatic alpha-amylase 2 shared papers
Alpha-amylase inhibitor helianthamide 1 shared papers

Literature · 13 cited papers

Potent human alpha-amylase inhibition by the beta-defensin-like protein helianthamide. ACS Cent. Sci. · 2016
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids. Biochemistry · 2002
Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase. Biochemistry · 2002
Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry · 2000
Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. Protein Sci. · 1999
The structure of human pancreatic alpha-amylase at 1.8-A resolution and comparisons with related enzymes. Protein Sci. · 1995
The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution. Biochemistry · 1994
Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases. Gene · 1984
A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A. Mol. Biol. Med. · 1984
Human pancreatic amylase is encoded by two different genes. Nucleic Acids Res. · 1988
Concerted evolution of human amylase genes. Mol. Cell. Biol. · 1988
… and 1 more in the literature graph

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