Envelope glycoprotein gp160

UniProt P04578 Organism Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) Gene env

Also known as: env

Function

Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.

Classification

Family (Pfam): PF00516 GP120, PF00517 GP41
InterPro: Gp120_core_sf, Gp160, GP41-like, HIV1_Gp120
Functional cluster: Viral Structural & Chromatin Proteins

Experimental structures · PDB · 131

1AIK X-ray 2.00A
1DF4 X-ray 1.45A
1DF5 X-ray 2.70A
1DLB X-ray 2.00A
1FAV X-ray 3.00A
1G9M X-ray 2.20A
1GC1 X-ray 2.50A
1GZL X-ray 1.80A
1K33 X-ray 1.75A
1K34 X-ray 1.88A
1MZI NMR
1RZJ X-ray 2.20A
… and 119 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

Drugs targeting this protein · 2

FOSTEMSAVIR inhibitor
FOSTEMSAVIR TROMETHAMINE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Envelope glycoprotein gp160 2 shared papers
T-cell surface glycoprotein CD4 1 shared papers
C-type lectin domain family 4 member M 2 shared papers
Envelope glycoprotein gp160 1 shared papers
CD209 antigen 2 shared papers
Guanylate-binding protein 5 1 shared papers
Guanylate-binding protein 2 1 shared papers
Protein disulfide-isomerase 1 shared papers
Furin 1 shared papers
Protein Rev 1 shared papers
Protein Nef 1 shared papers
Protein Vpu 1 shared papers

Literature · 45 cited papers

Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins. Cell Rep. · 2019
Conformational heterogeneity of the HIV envelope glycan shield. Sci. Rep. · 2017
Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein. Cell Rep. · 2016
Disruption of helix-capping residues 671 and 674 reveals a role in HIV-1 entry for a specialized hinge segment of the membrane proximal external region of gp41. J. Mol. Biol. · 2014
Rational HIV immunogen design to target specific germline B cell receptors. Science · 2013
Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. PLoS ONE · 2013
Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide. J. Biol. Chem. · 2012
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science · 2011
Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41. PLoS Pathog. · 2010
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120. Science · 2009
HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes. Cell · 2009
Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site. J. Mol. Biol. · 2008
… and 33 more in the literature graph

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