lmmol · Proteins

Neuraminidase

UniProt P03474 Organism Influenza B virus (strain B/Lee/1940) Gene NA EC 3.2.1.18

Also known as: NA

Function

Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.

Classification

Family (Pfam)
PF00064 Neur
InterPro
Glyco_hydro_34, Sialidase_sf
Functional cluster
Oxidoreductases, Catalases & Peroxidases

Experimental structures · PDB · 7

A predicted model is available from AlphaFold.

Gene Ontology · 7

Drugs targeting this protein · 4

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 6 cited papers

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