Neuraminidase
Also known as: NA
Function
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
Classification
- Family (Pfam)
- PF00064 Neur
- InterPro
- Glyco_hydro_34, Sialidase_Influenza_A/B, Sialidase_sf
- Functional cluster
- Oxidoreductases, Catalases & Peroxidases
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 10
- GO:0005576 extracellular region
- GO:0020002 host cell plasma membrane
- GO:0005886 plasma membrane
- GO:0055036 virion membrane
- GO:0004308 exo-alpha-sialidase activity
- GO:0046872 metal ion binding
- GO:0016504 peptidase activator activity
- GO:0005975 carbohydrate metabolic process
- GO:0046761 viral budding from plasma membrane
- GO:0019076 viral release from host cell
Drugs targeting this protein · 3
- OSELTAMIVIR PHOSPHATE inhibitor
- ZANAMIVIR inhibitor
- PERAMIVIR inhibitor
Related proteins · sequence + function similarity
- Neuraminidase 0.99
- Neuraminidase 0.99
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
- Neuraminidase 0.98
Co-cited proteins · studied together in the literature
- Neuraminidase 1 shared papers
- Neuraminidase 1 shared papers
- Neuraminidase 1 shared papers
- Neuraminidase 1 shared papers
- Hemagglutinin 2 shared papers
- PB2-S1 2 shared papers
- Nucleoprotein 2 shared papers
- Protein PA-X 2 shared papers
- Neuraminidase 1 shared papers
- Neuraminidase 1 shared papers
- Nuclear export protein 2 shared papers
- Matrix protein 2 2 shared papers
Literature · 7 cited papers
- Neuraminidase inhibitors for influenza. N. Engl. J. Med. · 2005
- Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol. Pharm. Bull. · 2005
- Assembly and budding of influenza virus. Virus Res. · 2004
- Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments. Virus Res. · 2004
- Plasmid-only rescue of influenza A virus vaccine candidates. Philos. Trans. R. Soc. Lond., B, Biol. Sci. · 2001
- Structure of the neuraminidase gene in human influenza virus A/PR/8/34. Nature · 1981
- Sequence variation at the 3' end of the neuraminidase gene from 39 influenza type A viruses. Virology · 1982