Genome polyprotein
Function
Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (Probable). Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle. During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions.
Classification
- Family (Pfam)
- PF20907 Flav_NS3-hel_C, PF01003 Flavi_capsid, PF07652 Flavi_DEAD, PF21659 Flavi_E_stem, PF02832 Flavi_glycop_C, PF00869 Flavi_glycoprot, PF01004 Flavi_M, PF00948 Flavi_NS1, PF01005 Flavi_NS2A, PF01002 Flavi_NS2B, PF01350 Flavi_NS4A, PF01349 Flavi_NS4B, PF00972 Flavi_NS5, PF20483 Flavi_NS5_thumb, PF01570 Flavi_propep, PF01728 FtsJ, PF00949 Peptidase_S7
- InterPro
- DNA/RNA_pol_sf, Env_glycoprot_M_flavivir, Env_glycoprot_M_sf_flavivir, Flav_gly_cen_dom_subdom1, Flavi_capsidC, Flavi_capsidC_sf, Flavi_DEAD, Flavi_E_Ig-like, Flavi_E_Stem/Anchor_dom, Flavi_E_Stem/Anchor_dom_sf, Flavi_Glycoprot_E_cen/dimer, Flavi_NS1, Flavi_NS2A, Flavi_NS2B, Flavi_NS3_S7, Flavi_NS4A, Flavi_NS4B, Flavi_NS5_thumb, Flavi_propep, Flavi_propep_sf, Flavi_RdRp, Flavi_RdRp_fingers/palm, Flavivir/Alphavir_Ig-like_sf, Gen_Poly_FLV, Glycoprot_cen/dimer_sf, Glycoprot_E_dimer_dom, GlyE_cen_dom_subdom2, Helicase_ATP-bd, Helicase_C-like, Ig_E-set, mRNA_cap_0/1_MeTrfase, NS3-hel_C_flaviviridae, P-loop_NTPase, Peptidase_S1_PA, RNA-dir_pol_PSvirus, RNA_MeTrfase_FtsJ_dom, SAM-dependent_MTases_sf
- Functional cluster
- DNA-Directed RNA Polymerase Subunits
Experimental structures · PDB · 26
- 1NA4 EM
- 1YKS X-ray 1.80A
- 3EVA X-ray 1.50A
- 3EVB X-ray 1.85A
- 3EVC X-ray 1.60A
- 3EVD X-ray 1.50A
- 3EVE X-ray 1.70A
- 3EVF X-ray 1.45A
- 5FFM X-ray 2.60A
- 5N6B X-ray 1.71A
- 6EPK X-ray 2.70A
- 6IW0 X-ray 3.60A
- … and 14 more
A predicted model is available from AlphaFold.
Gene Ontology · 29
- GO:0005576 extracellular region
- GO:0044167 host cell endoplasmic reticulum membrane
- GO:0044196 host cell nucleolus
- GO:0044220 host cell perinuclear region of cytoplasm
- GO:0019028 viral capsid
- GO:0019031 viral envelope
- GO:0055036 virion membrane
- GO:0005524 ATP binding
- GO:0016887 ATP hydrolysis activity
- GO:0003725 double-stranded RNA binding
- GO:0005525 GTP binding
- GO:0046872 metal ion binding
- GO:0004483 methyltransferase cap1 activity
- GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
- GO:0046983 protein dimerization activity
- GO:0003724 RNA helicase activity
- GO:0003968 RNA-directed RNA polymerase activity
- GO:0004252 serine-type endopeptidase activity
- GO:0005198 structural molecule activity
- GO:0075512 clathrin-dependent endocytosis of virus by host cell
- GO:0006351 DNA-templated transcription
- GO:0039654 fusion of virus membrane with host endosome membrane
- GO:0006508 proteolysis
- GO:0039520 symbiont-mediated activation of host autophagy
- GO:0052170 symbiont-mediated suppression of host innate immune response
- GO:0039564 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
- GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
- GO:0039694 viral RNA genome replication
- GO:0019062 virion attachment to host cell
Drugs targeting this protein · 1
- GALIDESIVIR inhibitor
Related proteins · sequence + function similarity
- Genome polyprotein 1.00
- Genome polyprotein 1.00
- Genome polyprotein 1.00
- Genome polyprotein 1.00
- Genome polyprotein 1.00
- Genome polyprotein 1.00
- Genome polyprotein 0.99
- Genome polyprotein 0.99
- Genome polyprotein 0.99
- Genome polyprotein 0.98
- Genome polyprotein 0.98
- Genome polyprotein 0.97
Co-cited proteins · studied together in the literature
- Genome polyprotein 1 shared papers
- Genome polyprotein 3 shared papers
- Genome polyprotein 1 shared papers
- Genome polyprotein 1 shared papers
- Genome polyprotein 2 shared papers
- Low-density lipoprotein receptor-related protein 4 1 shared papers
- Genome polyprotein 2 shared papers
- Very low-density lipoprotein receptor 1 shared papers
- Prolow-density lipoprotein receptor-related protein 1 1 shared papers
Literature · 40 cited papers
- Multiple LDLR family members act as entry receptors for yellow fever virus. Nature · 2025
- Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA. Proc. Natl. Acad. Sci. U.S.A. · 2016
- A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production. J. Virol. · 2015
- The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon. Cell Host Microbe · 2014
- Yellow fever virus NS2B/NS3 protease: hydrolytic properties and substrate specificity. Biochem. Biophys. Res. Commun. · 2011
- Interaction between the yellow fever virus nonstructural protein NS3 and the host protein Alix contributes to the release of infectious particles. Microbes Infect. · 2011
- The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure. RNA · 2009
- Analysis of flavivirus NS5 methyltransferase cap binding. J. Mol. Biol. · 2009
- Phosphorylation of yellow fever virus NS5 alters methyltransferase activity. Virology · 2008
- Yellow Fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. J. Virol. · 2008
- Yellow fever vaccine-associated viscerotropic disease and death in Spain. J. Clin. Virol. · 2006
- Characterization of a viscerotropic yellow fever vaccine variant from a patient in Brazil. Vaccine · 2006
- … and 28 more in the literature graph
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