Serum amyloid P-component

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Classification

Family (Pfam)

PF00354 Pentaxin

InterPro

ConA-like_dom_sf, Pentaxin_CS, Pentraxin_domain, PTX_dom

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 13

• 1GYK X-ray 2.20A
• 1LGN X-ray 2.80A
• 1SAC X-ray 2.00A
• 2A3W X-ray 2.20A
• 2A3X X-ray 3.00A
• 2A3Y X-ray 2.00A
• 2W08 X-ray 1.70A
• 3D5O X-ray 2.80A
• 3KQR X-ray 1.50A
• 4AVS X-ray 1.40A
• 4AVT X-ray 3.20A
• 4AVV X-ray 1.60A
• … and 1 more

A predicted model is available from AlphaFold.

Gene Ontology · 22

• GO:0072562 blood microparticle
• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005634 nucleus
• GO:0005509 calcium ion binding
• GO:0030246 carbohydrate binding
• GO:0001849 complement component C1q complex binding
• GO:0042802 identical protein binding
• GO:0051082 unfolded protein binding
• GO:0046790 virion binding
• GO:0006953 acute-phase response
• GO:0051131 chaperone-mediated protein complex assembly
• GO:0046597 host-mediated suppression of symbiont invasion
• GO:0045087 innate immune response
• GO:0044871 negative regulation by host of viral glycoprotein metabolic process
• GO:0002674 negative regulation of acute inflammatory response
• GO:1903019 negative regulation of glycoprotein metabolic process
• GO:0045656 negative regulation of monocyte differentiation
• GO:0048525 negative regulation of viral process
• GO:0061045 negative regulation of wound healing
• GO:0006457 protein folding

Drugs targeting this protein · 1

• MIRIDESAP cross-linking agent

Related proteins · sequence + function similarity

• Serum amyloid P-component 0.98
• Serum amyloid P-component 0.97
• Serum amyloid P-component 0.96
• Serum amyloid P-component 0.96
• Serum amyloid P-component 0.95
• Serum amyloid P-component 0.95
• C-reactive protein 0.95
• C-reactive protein 0.94
• C-reactive protein 0.94
• Female protein 0.94
• C-reactive protein 0.94
• C-reactive protein 0.93

Literature · 15 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Proteomic characterization of novel serum amyloid P component variants from human plasma and urine. Proteomics · 2004
• Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP. J. Mol. Biol. · 1997
• Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure. Proc. Natl. Acad. Sci. U.S.A. · 1994
• Structure of pentameric human serum amyloid P component. Nature · 1994
• The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis. J. Biol. Chem. · 1985
• … and 3 more in the literature graph