Spectrin alpha chain, erythrocytic 1

Function

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Classification

Family (Pfam)

PF08726 EFhand_Ca_insen, PF00018 SH3_1, PF00435 Spectrin

InterPro

EF-hand-dom_pair, EF-hand_Ca_insen, EF_hand_dom, SH3-like_dom_sf, SH3_domain, Spectrin/alpha-actinin, Spectrin_repeat

Functional cluster

ATP Synthase Gamma Subunit & related

Experimental structures · PDB · 3

• 1OWA NMR
• 3LBX X-ray 2.80A
• 5J4O X-ray 1.54A

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0015629 actin cytoskeleton
• GO:0030424 axon
• GO:0030054 cell junction
• GO:0042995 cell projection
• GO:0030864 cortical actin cytoskeleton
• GO:0032437 cuticular plate
• GO:0009898 cytoplasmic side of plasma membrane
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0008091 spectrin
• GO:0014731 spectrin-associated cytoskeleton
• GO:0051015 actin filament binding
• GO:0005509 calcium ion binding
• GO:0005200 structural constituent of cytoskeleton
• GO:0030036 actin cytoskeleton organization
• GO:0051693 actin filament capping
• GO:0007015 actin filament organization
• GO:0008360 regulation of cell shape

Disease associations

• elliptocytosis 2 MONDO:0007533
• pyropoikilocytosis, hereditary MONDO:0009948
• hereditary spherocytosis type 3 MONDO:0010053

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Spectrin alpha chain, erythrocytic 1 0.99
• Spectrin alpha chain 0.94
• Spectrin beta chain, erythrocytic 0.92
• Spectrin alpha chain, non-erythrocytic 1 0.92
• Spectrin alpha chain, non-erythrocytic 1 0.91
• Spectrin alpha chain, non-erythrocytic 1 0.91
• Spectrin alpha chain, non-erythrocytic 1 0.91
• Spectrin beta chain, erythrocytic 0.91
• Spectrin beta chain, non-erythrocytic 2 0.88
• Spectrin beta chain, non-erythrocytic 2 0.86
• Spectrin beta chain 0.84
• Spectrin beta chain, non-erythrocytic 1 0.84

Co-cited proteins · studied together in the literature

• Spectrin beta chain, erythrocytic 5 shared papers
• Spectrin alpha chain, erythrocytic 1 1 shared papers
• Basal cell adhesion molecule 1 shared papers

Literature · 32 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol. · 2009
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin. Br. J. Haematol. · 2004
• Solution structural studies on human erythrocyte alpha-spectrin tetramerization site. J. Biol. Chem. · 2003
• Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis. Hum. Mutat. · 1996
• Low expression allele alpha LELY of red cell spectrin is associated with mutations in exon 40 (alpha V/41 polymorphism) and intron 45 and with partial skipping of exon 46. J. Clin. Invest. · 1993
• Elliptopoikilocytosis associated with the alpha 469 His-->Pro mutation in spectrin Barcelona (alpha I/50-46b). Blood · 1993
• Spectrin Cagliari: an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer. J. Biol. Chem. · 1993
• Mild elliptocytosis associated with the alpha 34 Arg-->Trp mutation in spectrin Genova (alpha I/74). Blood · 1994
• … and 20 more in the literature graph