Tissue-type plasminogen activator

UniProt P00750 Organism Homo sapiens Gene PLAT EC 3.4.21.68

Also known as: PLAT

Function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).

Classification

Family (Pfam): PF00008 EGF, PF00039 fn1, PF00051 Kringle, PF00089 Trypsin
InterPro: EGF, Fibronectin_type1, Kringle, Kringle-like, Kringle_CS, Kringle_sf, Peptidase_S1_PA, Peptidase_S1_PA_chymotrypsin, Peptidase_S1A, Serine_Proteases_S1, Tissue_plasm_act, Trypsin_dom, TRYPSIN_HIS, TRYPSIN_SER
Functional cluster: Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 11

1A5H X-ray 2.90A
1BDA X-ray 3.35A
1PK2 NMR
1PML X-ray 2.38A
1RTF X-ray 2.30A
1TPG NMR
1TPK X-ray 2.40A
1TPM NMR
1TPN NMR
5BRR X-ray 3.16A
5ZLZ X-ray 3.58A

A predicted model is available from AlphaFold.

Gene Ontology · 24

Drugs targeting this protein · 1

AMINOCAPROIC ACID inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Apyrase 1 shared papers
Urokinase-type plasminogen activator 4 shared papers
Low-density lipoprotein receptor-related protein 1B 1 shared papers
Plasminogen activator inhibitor 1 3 shared papers
Longistatin 1 shared papers
Plasma serine protease inhibitor 1 shared papers
Alpha-2-macroglobulin receptor-associated protein 2 shared papers
Platelet-derived growth factor subunit B 1 shared papers
Urokinase plasminogen activator surface receptor 1 shared papers
Prolow-density lipoprotein receptor-related protein 1 1 shared papers
Sortilin-related receptor 1 shared papers

Literature · 31 cited papers

Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission. Nat. Commun. · 2024
Longistatin, a novel plasminogen activator from vector ticks, is resistant to plasminogen activator inhibitor-1. Biochem. Biophys. Res. Commun. · 2011
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand. Biochem. J. · 2004
An unappreciated role for RNA surveillance. Genome Biol. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. J. Biol. Chem. · 2001
Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility. Mol. Hum. Reprod. · 1999
Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA. EMBO J. · 1997
The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator. J. Mol. Biol. · 1996
The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator. Structure · 1995
Purification and characterization of a melanoma cell plasminogen activator. Eur. J. Biochem. · 1983
… and 19 more in the literature graph

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