lmmol · Proteins

Serine/threonine-protein kinase PAK 4

UniProt O96013 Organism Homo sapiens Gene KIAA1142, PAK4 EC 2.7.11.1

Also known as: KIAA1142, PAK4

Function

Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration.

Classification

Family (Pfam)
PF00786 PBD, PF00069 Pkinase
InterPro
CRIB_dom, CRIB_dom_sf, Kinase-like_dom_sf, PAK3-like, PAK_BD, Prot_kinase_dom, Protein_kinase_ATP_BS
Functional cluster
Serine/Threonine Protein Kinases

Experimental structures · PDB · 49

A predicted model is available from AlphaFold.

Gene Ontology · 26

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 32 cited papers

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