Glucagon-like peptide 2 receptor

Function

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Classification

Family (Pfam)

PF00002 7tm_2, PF02793 HRM

InterPro

7tmB1_GLP2R, GPCR_2, GPCR_2-like_7TM, GPCR_2_extracell_dom_sf, GPCR_2_extracellular_dom, GPCR_2_secretin-like, GPCR_2_secretin-like_CS

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 1

• 7D68 EM 3.00A

A predicted model is available from AlphaFold.

Gene Ontology · 8

• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0004930 G protein-coupled receptor activity
• GO:0004967 glucagon receptor activity
• GO:0017046 peptide hormone binding
• GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• GO:0007166 cell surface receptor signaling pathway
• GO:0008284 positive regulation of cell population proliferation

Drugs targeting this protein · 2

• TEDUGLUTIDE agonist
• FE 203799 agonist

Related proteins · sequence + function similarity

• Glucagon-like peptide 2 receptor 0.98
• Glucagon-like peptide 2 receptor 0.97
• Glucagon-like peptide 1 receptor 0.93
• Glucagon receptor 0.93
• Gastric inhibitory polypeptide receptor 0.92
• Glucagon-like peptide 1 receptor 0.92
• Glucagon-like peptide 1 receptor 0.92
• Gastric inhibitory polypeptide receptor 0.92
• Glucagon receptor 0.92
• Gastric inhibitory polypeptide receptor 0.92
• Glucagon receptor 0.91
• Gastric inhibitory polypeptide receptor 0.91

Co-cited proteins · studied together in the literature

• Glucagon-like peptide 2 receptor 1 shared papers

Literature · 2 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc. Natl. Acad. Sci. U.S.A. · 1999