Mitogen-activated protein kinase kinase kinase 13

Function

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Classification

Family (Pfam)

PF07714 PK_Tyr_Ser-Thr

InterPro

Kinase-like_dom_sf, MAP3K12_MAP3K13, MAPKKK13, Prot_kinase_dom, Ser-Thr/Tyr_kinase_cat_dom, Ser/Thr_kinase_AS, Ser/Thr_Kinases-Pseudokinases

Functional cluster

Homeobox & Zinc-Finger Transcription Factors

Gene Ontology · 20

• GO:0005737 cytoplasm
• GO:0016020 membrane
• GO:0005524 ATP binding
• GO:0019899 enzyme binding
• GO:0042802 identical protein binding
• GO:0106137 IkappaB kinase complex binding
• GO:0004709 MAP kinase kinase kinase activity
• GO:0046872 metal ion binding
• GO:0042803 protein homodimerization activity
• GO:0019901 protein kinase binding
• GO:0106310 protein serine kinase activity
• GO:0043539 protein serine/threonine kinase activator activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0007254 JNK cascade
• GO:0045773 positive regulation of axon extension
• GO:1905492 positive regulation of branching morphogenesis of a nerve
• GO:0043123 positive regulation of canonical NF-kappaB signal transduction
• GO:0014042 positive regulation of neuron maturation
• GO:0150012 positive regulation of neuron projection arborization
• GO:0051403 stress-activated MAPK cascade

Drugs targeting this protein · 1

• CEP-1347 inhibitor

Related proteins · sequence + function similarity

• Mitogen-activated protein kinase kinase kinase 13 1.00
• Mitogen-activated protein kinase kinase kinase 13 0.98
• Mitogen-activated protein kinase kinase kinase 13 0.97
• Mitogen-activated protein kinase kinase kinase 13-A 0.95
• Mitogen-activated protein kinase kinase kinase 13-B 0.93
• Mitogen-activated protein kinase kinase kinase dlk-1 0.86
• Mitogen-activated protein kinase kinase kinase dlk-1 0.81
• Microtubule-associated serine/threonine-protein kinase 2 0.79
• NUAK family SNF1-like kinase 1 0.77
• Microtubule-associated serine/threonine-protein kinase 4 0.77
• Mitogen-activated protein kinase kinase kinase 10 0.76
• Disks large-associated protein 2 0.75

Co-cited proteins · studied together in the literature

• C-Jun-amino-terminal kinase-interacting protein 1 1 shared papers
• Thioredoxin-dependent peroxide reductase, mitochondrial 1 shared papers
• Serine/threonine-protein kinase Nek3 1 shared papers
• Serine/threonine-protein kinase MARK2 1 shared papers
• Serine/threonine-protein kinase Nek2 1 shared papers
• Serine/threonine-protein kinase 3 1 shared papers

Literature · 9 cited papers

• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. Eur. J. Biochem. · 2003
• Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. J. Biochem. · 2001
• Identification and characterization of functional domains in a mixed lineage kinase LZK. FEBS Lett. · 2001
• Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. J. Biol. Chem. · 1997
• Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. Cell Growth Differ. · 1993