Motilin receptor

Function

Receptor for motilin.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GHS-R/MTLR, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM

Functional cluster

Nucleic Acid Metabolism & Repair Enzymes

Experimental structures · PDB · 4

• 8IBU EM 3.51A
• 8IBV EM 3.19A
• 9JMC EM 2.57A
• 9JMD EM 2.74A

A predicted model is available from AlphaFold.

Gene Ontology · 4

• GO:0005886 plasma membrane
• GO:0008528 G protein-coupled peptide receptor activity
• GO:0042562 hormone binding
• GO:0007186 G protein-coupled receptor signaling pathway

Drugs targeting this protein · 4

• MITEMCINAL FUMARATE agonist
• MITEMCINAL agonist
• ATILMOTIN agonist
• CAMICINAL agonist

Related proteins · sequence + function similarity

• Urotensin-2 receptor 0.90
• Urotensin-2 receptor 0.89
• Gastrin/cholecystokinin type B receptor 0.86
• Growth hormone secretagogue receptor type 1 0.84
• Neuropeptides B/W receptor type 1 0.84
• Gastrin/cholecystokinin type B receptor 0.84
• Galanin receptor type 3 0.84
• Neuromedin-U receptor 1 0.84
• Growth hormone secretagogue receptor type 1 0.84
• Gastrin/cholecystokinin type B receptor 0.84
• Sphingosine 1-phosphate receptor 5 0.84
• Gastrin/cholecystokinin type B receptor 0.83

Co-cited proteins · studied together in the literature

• G protein-coupled receptor 39 1 shared papers
• Growth hormone secretagogue receptor type 1 1 shared papers

Literature · 4 cited papers

• The DNA sequence and analysis of human chromosome 13. Nature · 2004
• Growth hormone secretagogue receptor family members and ligands. Endocrine · 2001
• Receptor for motilin identified in the human gastrointestinal system. Science · 1999
• Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics · 1997