Exportin-1

UniProt O14980 Organism Homo sapiens Gene CRM1, XPO1

Also known as: CRM1, XPO1

Function

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.

Classification

Family (Pfam): PF08767 CRM1_C, PF18777 CRM1_repeat, PF18784 CRM1_repeat_2, PF18787 CRM1_repeat_3, PF03810 IBN_N, PF08389 Xpo1
InterPro: ARM-like, ARM-type_fold, CRM1_repeat, Exp1_repeat_2, Exportin-1/Importin-b-like, Importin-beta_N, XPO1/5, XPO1_C_dom, XPO1_repeat_3
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 11

1W9C X-ray 2.30A
2L1L NMR
3GB8 X-ray 2.90A
4BSM X-ray 4.50A
4BSN X-ray 4.10A
5DIS X-ray 2.85A
6TVO X-ray 3.20A
7B51 X-ray 2.58A
8URJ EM 4.25A
9B62 EM 2.90A
9HFL EM 2.62A

A predicted model is available from AlphaFold.

Gene Ontology · 29

Drugs targeting this protein · 1

SELINEXOR inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

60S ribosomal export protein NMD3 1 shared papers
Ran-binding protein 3 3 shared papers
GTP-binding nuclear protein Ran 8 shared papers
Nucleoprotein 1 shared papers
Protein Rev 2 shared papers
Nucleoporin NUP42 1 shared papers
Exportin-1 1 shared papers
mRNA export factor ICP27 homolog 1 shared papers
Phosphorylated adapter RNA export protein 1 shared papers
Bcl-2-related ovarian killer protein 1 shared papers
Activator of 90 kDa heat shock protein ATPase homolog 1 1 shared papers
HCLS1-associated protein X-1 1 shared papers

Literature · 48 cited papers

A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery. RNA · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing. FEBS J. · 2013
NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Nucleic Acids Res. · 2012
Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A). FEBS Lett. · 2012
Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity. J. Biol. Chem. · 2012
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc. Natl. Acad. Sci. U.S.A. · 2011
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine. PLoS ONE · 2011
SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus. PLoS ONE · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
… and 36 more in the literature graph

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