Cell division cycle 7-related protein kinase

Function

Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

DNA-Binding Transcription Factors & PPR Proteins

Experimental structures · PDB · 9

• 4F99 X-ray 2.33A
• 4F9A X-ray 2.17A
• 4F9B X-ray 2.50A
• 4F9C X-ray 2.08A
• 5UWQ X-ray 2.28A
• 5UWR X-ray 2.24A
• 6YA6 X-ray 1.44A
• 6YA7 X-ray 1.67A
• 6YA8 X-ray 1.79A

A predicted model is available from AlphaFold.

Gene Ontology · 21

• GO:0005737 cytoplasm
• GO:0045171 intercellular bridge
• GO:0072686 mitotic spindle
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding
• GO:0004672 protein kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0044770 cell cycle phase transition
• GO:0051301 cell division
• GO:0000727 double-strand break repair via break-induced replication
• GO:0000082 G1/S transition of mitotic cell cycle
• GO:0033314 mitotic DNA replication checkpoint signaling
• GO:0031573 mitotic intra-S DNA damage checkpoint signaling
• GO:0008284 positive regulation of cell population proliferation
• GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
• GO:0010571 positive regulation of nuclear cell cycle DNA replication
• GO:0007165 signal transduction

Drugs targeting this protein · 2

• BMS-863233 inhibitor
• SIMUROSERTIB inhibitor

Related proteins · sequence + function similarity

• Cell division cycle 7-related protein kinase 0.94
• Protein SUPPRESSOR OF PHYA-105 1 0.63
• Probable serine/threonine-protein kinase WNK4 0.63
• Protein SPA1-RELATED 2 0.62
• Serine/threonine-protein kinase ATG1b 0.60
• Serine/threonine-protein kinase KIPK1 0.60
• Lysine-specific demethylase REF6 0.60
• Serine/threonine-protein kinase ATG1a 0.60
• Increased DNA methylation 1 0.59
• Probable serine/threonine-protein kinase WNK10 0.59
• Probable lysine-specific demethylase SE14 0.58
• Lysine-specific demethylase ELF6 0.58

Co-cited proteins · studied together in the literature

• Protein DBF4 homolog B 3 shared papers
• Protein DBF4 homolog A 2 shared papers
• Claspin 1 shared papers
• DNA replication licensing factor MCM2 2 shared papers
• DNA replication licensing factor MCM4 1 shared papers
• Claspin 1 shared papers

Literature · 15 cited papers

• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. Nat. Commun. · 2016
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• Cdc7 is an active kinase in human cancer cells undergoing replication stress. J. Biol. Chem. · 2007
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J. Biol. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Drf1, a novel regulatory subunit for human Cdc7 kinase. EMBO J. · 2002
• A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Mol. Cell. Biol. · 1999
• … and 3 more in the literature graph