Myosin-7B

Function

Involved in muscle contraction.

Classification

Family (Pfam)

PF00063 Myosin_head, PF02736 Myosin_N, PF01576 Myosin_tail_1

InterPro

Kinesin_motor_dom_sf, Myosin_head_motor_dom-like, Myosin_S1_N, Myosin_tail, P-loop_NTPase, SH3_Myosin, XRCC4-like_C

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 11

• GO:0097512 cardiac myofibril
• GO:0005737 cytoplasm
• GO:0016020 membrane
• GO:0032982 myosin filament
• GO:0016460 myosin II complex
• GO:0051015 actin filament binding
• GO:0005524 ATP binding
• GO:0000146 microfilament motor activity
• GO:1905289 regulation of CAMKK-AMPK signaling cascade
• GO:0086004 regulation of cardiac muscle cell contraction
• GO:0051480 regulation of cytosolic calcium ion concentration

Drugs targeting this protein · 3

• OMECAMTIV MECARBIL activator
• MAVACAMTEN inhibitor
• DANICAMTIV activator

Related proteins · sequence + function similarity

• Myosin-7B 0.98
• Myosin-15 0.93
• Myosin-16 0.91
• Myosin-11 0.90
• Unconventional myosin-Ih 0.89
• Myosin-11 0.89
• Myosin-2 heavy chain 0.89
• Myosin heavy chain, striated muscle 0.88
• Myosin-9 0.88
• Myosin-11 0.88
• Myosin-13 0.88
• Myosin-1 0.88

Co-cited proteins · studied together in the literature

• Myosin-15 1 shared papers
• Calcium-binding protein 39-like 1 shared papers
• Bridge-like lipid transfer protein family member 2 1 shared papers
• Myosin-14 1 shared papers

Literature · 6 cited papers

• Serological identification of immunogenic antigens in acute monocytic leukemia. Leuk. Res. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. Mol. Biol. Evol. · 2002
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
• Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. · 2000