Envelope phospholipase OPG057
Also known as: OPG057
Function
Major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell. Produces the wrapped form of virus that is required for cell-to-cell spread. Acts as a lipase with broad specificity including phospholipase C, phospholipase A, and triacylglycerol lipase activities.
Classification
- Family (Pfam)
- PF13918 PLDc_3
- InterPro
- Diverse_PLD-related, PLDc_3, PLipase_D/transphosphatidylase
- Functional cluster
- Zinc-Finger Nucleic-Acid-Binding & Methyltransferases
Gene Ontology · 6
Drugs targeting this protein · 1
- TECOVIRIMAT MONOHYDRATE inhibitor
Related proteins · sequence + function similarity
- Envelope phospholipase OPG057 1.00
- Envelope phospholipase OPG057 1.00
- Envelope phospholipase OPG057 1.00
- Envelope phospholipase OPG057 1.00
- Envelope phospholipase OPG057 1.00
- Envelope phospholipase OPG057 0.99
- Envelope protein F13 homolog 0.89
- Virion nicking-joining enzyme 0.77
- Virion nicking-joining enzyme 0.76
- Virion nicking-joining enzyme 0.76
- Envelope protein F13 homolog 0.72
- 5'-3' exonuclease PLD3 0.70
Literature · 1 cited papers
- Exportation of Monkeypox virus from the African continent. J. Infect. Dis. · 2022
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