Entrectinib
SMILES CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1
Structure
2D skeletal formula · rendered by chemkit from PubChem 2D coordinates.
Pseudo-3D ball-and-stick · chemkit, from PubChem 3D conformer coordinates.
Protein targets · 5 targets
- High affinity nerve growth factor receptor P04629 · inhibitor · Neurotrophic tyrosine kinase receptor inhibitor
- BDNF/NT-3 growth factors receptor Q16620 · inhibitor · Neurotrophic tyrosine kinase receptor inhibitor
- NT-3 growth factor receptor Q16288 · inhibitor · Neurotrophic tyrosine kinase receptor inhibitor
- Proto-oncogene tyrosine-protein kinase ROS P08922 · inhibitor · Proto-oncogene tyrosine-protein kinase ROS inhibitor
- ALK tyrosine kinase receptor Q9UM73 · inhibitor · ALK tyrosine kinase receptor inhibitor
Each resolved target links to its lmmol protein document; action and mechanism are from the bioactivity record.
A document in the lmmol reference corpus — a real compound (PubChem / ChEMBL identity, chemkit-rendered structure) cross-linked to the protein documents it targets. Hover any link to preview its target.