:root{--ink:#1a2330;--muted:#5b6b7f;--accent:#2a5db0;--line:#e3e8f0;--bg:#fff}
*{box-sizing:border-box}body{margin:0;background:#f6f8fb;color:var(--ink);
font:17px/1.7 -apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif}
.wrap{max-width:48rem;margin:0 auto;padding:1.5rem 1.2rem 4rem}
.site{font-size:.85rem;color:var(--muted);margin:0 0 1.2rem}.site a{color:var(--accent);text-decoration:none}
article{background:var(--bg);border:1px solid var(--line);border-radius:14px;padding:2rem 2.1rem}
h1{font-size:clamp(1.5rem,3vw,1.95rem);line-height:1.22;margin:0 0 .5rem}
h2{font-size:1.12rem;margin:1.7rem 0 .55rem;font-weight:650}
.byline{color:var(--muted);font-size:.97rem;margin:0 0 1rem}.byline strong{color:var(--ink)}
.idmeta{font-size:.93rem;color:var(--muted);margin:0 0 .2rem;display:flex;flex-wrap:wrap;gap:.2rem 1.1rem}
.idmeta .k{color:var(--muted);font-weight:600;margin-right:.3rem;font-size:.82rem;text-transform:uppercase;letter-spacing:.02em}
.smiles{font-size:.9rem;color:var(--muted);margin:.1rem 0 1rem;word-break:break-all}
.smiles .k{font-weight:600;font-size:.82rem;text-transform:uppercase;letter-spacing:.02em;margin-right:.3rem}
.smiles code{font-size:.9rem;color:var(--ink)}
section{margin:0}p{margin:0 0 .8rem}
ul.targets{list-style:none;padding:0;margin:.2rem 0 0}ul.targets li{margin:.3rem 0;line-height:1.5}
ul.targets .act{font-size:.82rem;color:var(--accent);text-transform:lowercase}
ul.targets .moa{font-size:.84rem;color:var(--muted)}
.dim{color:var(--muted);font-size:.85rem;font-weight:400}
.depict{display:flex;flex-wrap:wrap;gap:1rem;justify-content:center}
.depict-2d,.depict-3d{flex:1 1 18rem;min-width:16rem}
.depict .cap{font-size:.82rem;color:var(--muted);text-align:center;margin:.2rem 0 0;line-height:1.45}
ul.compoundlist{list-style:none;padding:0;margin:1rem 0 0}
ul.compoundlist li{padding:.6rem 0;border-top:1px solid var(--line)}
ul.compoundlist li:first-child{border-top:none}
ul.compoundlist a{color:var(--accent);text-decoration:none;font-weight:600;font-size:1.02rem}
ul.compoundlist .meta{color:var(--muted);font-size:.85rem;margin-top:.1rem}
.foot{margin-top:2rem;border-top:1px solid var(--line);padding-top:1rem;font-size:.9rem;color:var(--muted)}
a.xref{color:inherit;text-decoration:none;cursor:pointer;border-bottom:1px solid transparent;
transition:border-color .12s ease,color .12s ease}
a.xref:hover{border-bottom:1px dotted currentColor;color:var(--accent)}